Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF1ZE6)

Drug Name

Benzofuran-2-yl(indolin-1-yl)methanone Drug Info

Synonyms

CHEMBL496155; benzofuran-2-yl(indolin-1-yl)methanone; AC1LFLO9; Oprea1_781741; SCHEMBL2757847; MolPort-002-146-725; ZINC272979; BDBM50265522; ZINC 00272979; AKOS001474069; MCULE-1146733513; SR-01000206937; 1-benzofuran-2-yl(2,3-dihydroindol-1-yl)methanone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 780029
TTD Drug ID: DMF1ZE6

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting MIF messenger RNA (MIF mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 112690	DM6PO0N	Discovery agent	N.A.	Investigative	[2]
Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate	DM7FPX8	Discovery agent	N.A.	Investigative	[1]
ISIS 112724	DMB2O1Y	Discovery agent	N.A.	Investigative	[2]
3-benzyl-6-methylbenzo[d]oxazol-2(3H)-one	DMGPKIY	Discovery agent	N.A.	Investigative	[3]
2-(4-hydroxystyryl)quinolin-8-ol	DM8GBH4	Discovery agent	N.A.	Investigative	[1]
7-hydroxy-3-phenyl-2H-chromen-2-one	DM2ZE8U	Discovery agent	N.A.	Investigative	[1]
6-phenylpyridazin-3-yl thiophene-2-carboxylate	DMXTV1B	Discovery agent	N.A.	Investigative	[4]
3-benzyl-5-fluorobenzo[d]oxazol-2(3H)-one	DMZ85NC	Discovery agent	N.A.	Investigative	[3]
ISIS 112696	DMXZS4Y	Discovery agent	N.A.	Investigative	[2]
4-((pyridin-4-ylthio)methyl)benzene-1,2-diol	DM7X2AY	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MIF messenger RNA (MIF mRNA)	TT6804T	MIF_HUMAN	Inhibitor	[1]

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References

1	Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24.
2	US patent application no. 6,268,151, Antisense modulation of macrophage migration inhibitory factor expression.
3	Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4.
4	An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40.
5	Classification of chemical compounds by protein-compound docking for use in designing a focused library. J Med Chem. 2006 Jan 26;49(2):523-33.