Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF5794)

Drug Name

URO-902 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Overactive bladder	GC50.0	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Calcium-activated potassium channel KCa1.1 (KCNMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CROMOGLYCATE LISETIL HYDROCHLORIDE	DM129T7	Asthma	CA23	Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-activated potassium channel KCa1.1 (KCNMA1)	TTE87WJ	KCMA1_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT04211831) An Exploratory Phase 2a Study Evaluating the Efficacy and Safety of URO-902 in Subjects With Overactive Bladder and Urge Urinary Incontinence. U.S.National Institutes of Health.
2	Evaluating the safety and potential activity of URO-902 (hMaxi-K) gene transfer by intravesical instillation or direct injection into the bladder wall in female participants with idiopathic (non-neurogenic) overactive bladder syndrome and detrusor overactivity from two double-blind, imbalanced, placebo-controlled randomized phase 1 trials. Neurourol Urodyn. 2020 Feb;39(2):744-753.
3	The significance of chloride in the inhibitory action of disodium cromoglycate on immunologically-stimulated rat peritoneal mast cells. Biochim Biophys Acta. 2011 Sep;1810(9):867-74.