Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF5KNO)

Drug Name

OTSSP167 Drug Info

Synonyms

OTSSP 167; OTSSP-167; AMX10201

Indication

Disease Entry	ICD 11	Status	REF
Acute lymphoblastic leukaemia	2A85	Phase 1	[1]
Acute myeloid leukaemia	2A60	Phase 1	[1]
Breast cancer	2C60-2C65	Phase 1	[1]
Chronic lymphocytic leukaemia	2A82.0	Phase 1	[1]
Myelodysplastic syndrome	2A37	Phase 1	[1]
Myeloproliferative neoplasm	2A20	Phase 1	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Maternal embryonic leucine zipper kinase (MELK)	TT5MN2U	MELK_HUMAN	Inhibitor	[1]
Tyrosine-protein kinase MELK (MELK)	TTBZOTY	MELK_HUMAN	Inhibitor	[2]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec;3(12):1629-40.