Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF6Z5T)

Drug Name

Glecaprevir; pibrentasvir Drug Info

Synonyms

pibrentasvir; Maviret; Mavyret; Glecaprevir / pibrentasvir; Glecaprevir and pibrentasvir; ABT-493/ABT-530; Glecaprevir mixture with pibrentasvir; ABT-493 / ABT-530; S900007520

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Approved	[1]

Cross-matching ID

PubChem CID: 66828839; 58031952
TTD Drug ID: DMF6Z5T

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simeprevir	DMLUA9D	Chronic HCV-1 infection	1E51.1	Approved	[2]
BOCEPREVIR	DMBSHMF	Hepatitis C virus infection	1E51.1	Approved	[3]
Telaprevir	DMMRV29	Hepatitis C virus infection	1E51.1	Approved	[3]
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Drug(s) Targeting Hepatitis C virus Non-structural 5A (HCV NS5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daclatasvir	DMSFK9V	Hepatitis C virus infection	1E51.1	Approved	[4]
ABT-267	DMNQ869	Hepatitis C virus infection	1E51.1	Phase 3	[5]
MK-8742	DMK301H	Hepatitis C virus infection	1E51.1	Phase 3	[6]
Ravidasvir	DM1LFUN	Hepatitis C	1E51	Phase 2/3	[7]
GS-5885	DMSL3DX	Hepatitis C virus infection	1E51.1	Phase 2	[8]
PPI-668	DM4EHVB	Hepatitis C virus infection	1E51.1	Phase 2	[9]
ACH-3102	DM0RPY5	Hepatitis C virus infection	1E51.1	Phase 2	[9]
AZD-2836	DMT2FAP	Hepatitis C virus infection	1E51.1	Phase 1/2	[10]
BMS-824383	DMPQ5XC	Hepatitis C virus infection	1E51.1	Phase 1	[4]
PPI-461	DMTOXLG	Hepatitis C virus infection	1E51.1	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis C virus Non-structural 5A (HCV NS5A)	TTCJ2X8	POLG_HCV1	Inhibitor	[1]
Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A)	TTHC7JD	POLG_HCV1	Inhibitor	[1]

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References

1	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
3	2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
4	2011 Pipeline of Bristol-Myers Squibb.
5	Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A. J Med Chem. 2014 Mar 13;57(5):2047-57.
6	Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity. ChemMedChem. 2013 Dec;8(12):1930-40.
7	Clinical pipeline report, company report or official report of Presidio Pharmaceuticals.
8	Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J Med Chem. 2014 Mar 13;57(5):2033-46.
9	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
10	TARGETING THE NS5A PROTEIN OF HCV: AN EMERGING OPTION. Drugs Future. 2011 September; 36(9): 691-711.