Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF71B3)

• Drug Name: RS-102895 Drug Info
• Synonyms: RS102895; RS-102895; GTPL779; SCHEMBL9972649; CHEMBL1593104; CHEBI:93458; ZINC2563946; BCP05302; HY-18611A; AKOS030526775; CS-3487; NCGC00092306-02; AJ-40982; KB-62464; BRD-K83063356-003-01-7; 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one; 1-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4-piperidin]-2(1H)-one hydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10000456
  ChEBI ID: CHEBI:93458
  TTD Drug ID: DMF71B3

Molecule-Related Drug Atlas

Drug(s) Targeting C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cenicriviroc	DM4V8WF	Human immunodeficiency virus infection	1C62	Phase 2	[3]
MLN1202	DM24SOL	Metastatic cancer	2D50-2E2Z	Phase 2	[4]
BMS-813160	DMKY638	Diabetic nephropathy	GB61.Z	Phase 2	[5]
CCX-140	DMJ9XCO	Diabetic nephropathy	GB61.Z	Phase 2	[6]
AZD-2423	DMF34UY	Chronic obstructive pulmonary disease	CA22	Phase 2	[7]
CCX872	DMPVAUT	Pancreatic tumour	2C10	Phase 2	[8]
MK-0812	DMRT8K4	Multiple sclerosis	8A40	Phase 2	[9]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[10]
TAK-202	DMVYEFZ	Melanoma	2C30	Phase 1	[11]
OPL-CCL2-LPM	DM3HOUX	Arthritis	FA20	Phase 1	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 2 (CCR2)	TTFZYTO	CCR2_HUMAN	Antagonist	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 779).
• [2] Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within t... J Biol Chem. 2000 Aug 18;275(33):25562-71.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
• [5] A dual CCR2/CCR5 chemokine antagonist, BMS-813160. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24.
• [6] Present and future in the treatment of diabetic kidney disease. J Diabetes Res. 2015;2015:801348.
• [7] CA patent application no. 841416, Method of selecting therapeutic indications.
• [8] Therapeutic use of a clinical stage CCR2 inhibitor, CCX872, in obesity-associated steatohepatitis. The Lancet Volume 383, Supplement 1, 26 February 2014, Pages S78.
• [9] Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.
• [10] Incyte Announces Second Quarter 2005 Financial Results; Reports Positive Phase IIb Results for Reverset in Treatment-Experienced HIV Patients. Incyte Corporation. 2005.
• [11] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [12] Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol. 2009 February; 155(2): 295-303.