Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF7TBW)

Drug Name

CATPB Drug Info

Synonyms

(s)-3-(2-(3-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid; GTPL6487; SCHEMBL2312533; CATPB, > ZINC118616157; AKOS030210965; 1322598-09-3; (3S)-3-[2-(3-chlorophenyl)acetamido]-4-[4-(trifluoromethyl)phenyl]butanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 53308747
TTD Drug ID: DMF7TBW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Free fatty acid receptor 2 (FFAR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GLPG0974	DMXO4T8	Abortion	JA00	Phase 2	[3]
HL-018	DMT3HKZ	Diabetic complication	5A2Y	Phase 1	[4]
(S)-4-CMTB	DMI12X9	Discovery agent	N.A.	Investigative	[2]
isobutyric acid	DMX4VY9	Discovery agent	N.A.	Investigative	[5]
1-methylcyclopropanecarboxylic acid	DMDIH07	Discovery agent	N.A.	Investigative	[6]
pentanoic acid	DM56RAX	Discovery agent	N.A.	Investigative	[7]
trans-2-methylcrotonic acid	DMHJM0B	Discovery agent	N.A.	Investigative	[6]
AMG7703	DMJ6L9U	Discovery agent	N.A.	Investigative	[8]
PMID23589301C1	DMB7TE6	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Free fatty acid receptor 2 (FFAR2)	TT0FYAN	FFAR2_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6487).
2	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. J Biol Chem. 2012 Nov 30;287(49):41195-209.
3	Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem. 2014 Dec 11;57(23):10044-57.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 226).
5	Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 2003 Jul 11;278(28):25481-9.
6	Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J Biol Chem. 2011 Mar 25;286(12):10628-40.
7	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003 Mar 28;278(13):11312-9.
8	Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol. 2011 Jul;80(1):163-73.
9	Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. J Biol Chem. 2013 Jun 14;288(24):17296-312.