Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFBRSL)

• Drug Name: N-(2-phenylcyclopropyl) amino acid derivative 3 Drug Info
• Synonyms: PMID27019002-Compound-19b
• Cross-matching ID: TTD Drug ID: DMFBRSL

Molecule-Related Drug Atlas

Drug(s) Targeting Lysine-specific histone demethylase 1 (LSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IMG-7289	DML9AVG	Acute myeloid leukaemia	2A60	Phase 2	[2]
CC-90011	DM0EDHJ	Lymphoma	2A80-2A86	Phase 2	[2]
CC-90011	DM0EDHJ	Lymphoma	2A80-2A86	Phase 2	[3]
Vafidemstat	DM64ZGY	Alzheimer disease	8A20	Phase 2	[4]
ORY-2001	DMYM0UY	Alzheimer disease	8A20	Phase 2	[5]
INCB59872	DMRLV7G	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
GSK2879552	DMT3V2W	Small-cell lung cancer	2C25.Y	Phase 1	[6]
Seclidemstat	DMCP7SD	Ewing sarcoma	2B52	Phase 1	[7]
TAS-1440	DMHIA7Y	Acute myeloid leukaemia	2A60	Phase 1	[8]
Tarnylcypromine derivative 2	DMEJR2F	N. A.	N. A.	Patented	[1]

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[9]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[10]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[11]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[12]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[13]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[14]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[15]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[16]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[17]
Budipine	DMODHQI	Migraine	8A80	Approved	[18]

Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[19]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[20]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[21]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[22]
TRYPTAMINE	DMAFPHB	N. A.	N. A.	Phase 3	[23]
Psoralen	DMIZJ8M	N. A.	N. A.	Phase 3	[24]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[25]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[26]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[27]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysine-specific histone demethylase 1 (LSD)	TTNR0UQ	KDM1A_HUMAN	Inhibitor	[1]
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

References

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• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529.
• [4] Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis. Pharmaceutics. 2022 Jul 6;14(7):1420.
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• [12] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490).
• [13] 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
• [14] Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Neurotox Res. 2009 Aug;16(2):148-59.
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• [16] Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H821-8.
• [17] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [18] Multiple mechanisms of action: the pharmacological profile of budipine. J Neural Transm Suppl. 1999;56:83-105.
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• [20] Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. Int J Neuropsychopharmacol. 2009 Mar 11:1-11.
• [21] Further investigation into the mechanism of tachykinin NK(2) receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci. 2009 May;110(1):122-6.
• [22] MAOIs in the contemporary treatment of depression. Neuropsychopharmacology. 1995 May;12(3):185-219.
• [23] Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.
• [24] Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80.
• [25] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
• [26] Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
• [27] Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31.
• [28] Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases. Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40.