General Information of Drug (ID: DMFEQ6S)

Drug Name
3,5-DHPG Drug Info
Synonyms 3,5-dihydroxyphenylglycine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
108001
ChEBI ID
CHEBI:93822
CAS Number
CAS 146255-66-5
TTD Drug ID
DMFEQ6S

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PF-1913539 DMXEU14 Alzheimer disease 8A20 Discontinued in Phase 3 [4]
AZD8529 DMEQ2N1 Schizophrenia 6A20 Discontinued in Phase 2 [5]
AZD-9272 DMYSBN3 Neuropathic pain 8E43.0 Discontinued in Phase 1 [6]
NPS-2390 DMMRY0Z Cerebrovascular ischaemia 8B1Z Preclinical [7]
A-841720 DMSO8IE Pain MG30-MG3Z Preclinical [8]
LY-367385 DM98POQ Neurological disorder 6B60 Terminated [9]
[3H]quisqualate DMDQBTX Discovery agent N.A. Investigative [10]
L-CCG-I DMPZ8XH Discovery agent N.A. Investigative [3]
(1S,3R)-ACPD DM5DOAF Discovery agent N.A. Investigative [3]
(+)-MCPG DMG5QJB Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AFQ056 DMMHSLC Fragile X syndrome LD55 Phase 2/3 [11]
ADX-48621 DM6GTMD Parkinson disease 8A00.0 Phase 2/3 [12]
RG-7090 DMX8JYN Fragile X syndrome LD55 Phase 2 [13]
STX-107 DMLNKX7 Autism spectrum disorder 6A02 Phase 2 [14]
ADX10059 DMGVKHQ Anxiety disorder 6B00-6B0Z Phase 2 [15]
McN3377 DMTCADJ Fragile X syndrome LD55 Phase 1/2 [16]
MK-3328 DMW2O5D Alzheimer disease 8A20 Phase 1 [17]
[3H]fenobam DMBOXA1 Allodynia MB40.1 Phase 1 [18]
RG7342 DMIW5NG Schizophrenia 6A20 Phase 1 [19]
BMS-984923 DMFNDUL Alzheimer disease 8A20 Phase 1 [20]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Metabotropic glutamate receptor 1 (mGluR1) TTVBPDM GRM1_HUMAN Agonist [2]
Metabotropic glutamate receptor 5 (mGluR5) TTHS256 GRM5_HUMAN Agonist [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1367).
2 [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93.
3 Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601.
4 Pfizer. Product Development Pipeline. March 31 2009.
5 Clinical pipeline report, company report or official report of AstraZeneca (2009).
6 Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
7 Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47.
8 Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol. 2007 Jul;18(4):273-81.
9 Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur J Pharmacol. 1999 Feb 26;368(1):17-24.
10 Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glut... J Biol Chem. 2003 Mar 7;278(10):8340-7.
11 Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects. Drug Metab Dispos. 2013 Sep;41(9):1626-41.
12 Pipeline of Addex Pharma. Addex Pharma. 2009.
13 The challenges of clinical trials in fragile X syndrome. Psychopharmacology (Berl) 2014; 231(6): 1237-1250.
14 Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents. J Can Acad Child Adolesc Psychiatry. 2014 February; 23(1):20-30.
15 A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and... Gut. 2009 Sep;58(9):1192-9.
16 Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
17 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).
18 Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agon... J Pharmacol Exp Ther. 2005 Nov;315(2):711-21.
19 Clinical pipeline report, company report or official report of Roche.
20 Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88.