Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFEYLS)

Drug Name

[3H]GlySar Drug Info

Synonyms

[3H]-GlySar; tritiated glycylsarcosine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 93131
ChEBI ID: CHEBI:155876
CAS Number: CAS 29816-01-1
TTD Drug ID: DMFEYLS
VARIDT Drug ID: DR01125

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Solute carrier family 15 member 2 (SLC15A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lys[Z(NO2)]-Pro	DMJX4GA	Discovery agent	N.A.	Investigative	[3]
[14C]GlySar	DMGLQ72	Discovery agent	N.A.	Investigative	[3]
[11C]GlySar	DM5Q08F	Discovery agent	N.A.	Investigative	[3]
Lys[Z(NO2)]-Lys[Z(NO2)]	DMH0Q9V	Discovery agent	N.A.	Investigative	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[21]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[22]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[24]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[24]
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Drug(s) Targeting Solute carrier family 15 member 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lys[Z(NO2)]-Pro	DMJX4GA	Discovery agent	N.A.	Investigative	[7]
[14C]GlySar	DMGLQ72	Discovery agent	N.A.	Investigative	[2]
[11C]GlySar	DM5Q08F	Discovery agent	N.A.	Investigative	[2]
4-AMBA	DMYNASR	Discovery agent	N.A.	Investigative	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[10]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[13]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[17]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[14]
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⏷ Show the Full List of 14 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 15 member 1 (SLC15A1)	TT5LF3C	S15A1_HUMAN	Modulator	[2]
Solute carrier family 15 member 2 (SLC15A2)	TT27Q3A	S15A2_HUMAN	Modulator	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Solute carrier family 15 member 1 (SLC15A1)	OT1P16B5	S15A1_HUMAN	Gene/Protein Processing	[4]
Solute carrier family 15 member 2 (SLC15A2)	OTDV7YES	S15A2_HUMAN	Regulation of Drug Effects	[5]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4659).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 984).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 985).
4	Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatr Dis Treat. 2010 Jun 24;6:317-27.
5	Completing the Enalaprilat Excretion Pathway-Renal Handling by the Proximal Tubule. Pharmaceutics. 2020 Sep 30;12(10):935. doi: 10.3390/pharmaceutics12100935.
6	Defining minimal structural features in substrates of the H(+)/peptide cotransporter PEPT2 using novel amino acid and dipeptide derivatives. Mol Pharmacol. 2002 Jan;61(1):214-21.
7	A novel inhibitor of the mammalian peptide transporter PEPT1. Biochemistry. 2001 Apr 10;40(14):4454-8.
8	Activation of vagal afferents in the rat duodenum by protein digests requires PepT1. J Nutr. 2005 Jun;135(6):1491-5.
9	Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
10	Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
11	In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors. Pharm Res. 2005 Apr;22(4):512-7. doi: 10.1007/s11095-005-2505-y. Epub 2005 Apr 7.
12	Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
13	Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro. Int J Pharm. 2015 Nov 10;495(1):588-598. doi: 10.1016/j.ijpharm.2015.09.042. Epub 2015 Sep 21.
14	Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011 Feb;77(2):327-31. doi: 10.1016/j.ejpb.2010.12.009. Epub 2010 Dec 13.
15	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
16	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
17	Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
18	Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
19	Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
20	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
21	Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
22	Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
23	Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population. Sci Rep. 2017 Dec 12;7(1):17379. doi: 10.1038/s41598-017-17731-1.
24	Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.