Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFK5IX)

Drug Name

MAK683 Drug Info

Synonyms

XLIBABIFOBYHSV-UHFFFAOYSA-N; EED inhibitor-1; 1951408-58-4; MAK-683; N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine; N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine; SCHEMBL17841485; EX-A1723; BCP29116; ACN-053195; CS-8054; AC-30344; HY-103663

Indication

Disease Entry	ICD 11	Status	REF
Diffuse large B-cell lymphoma	2A81	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 121412508
CAS Number: CAS 1951408-58-4
TTD Drug ID: DMFK5IX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Embryonic ectoderm development protein (EED)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ORIC-944	DM0L8R9	Prostate cancer	2C82.0	Phase 1	[2]
A-395	DMSTZ14	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Embryonic ectoderm development protein (EED)	TTFNJ4R	EED_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of ORIC Pharmaceuticals
3	The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 Apr;13(4):389-395.