Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFXUT8)

Drug Name
Oxymetholone Drug Info
Synonyms oxymetholone; Anasterone; 434-07-1; HMS3393H15
Indication
Disease Entry ICD 11 Status REF
Aplastic anemia 3A70 Approved [1]
Aregenerative anemia Approved [2]
Diamond-Blackfan anemia Approved [2]
Cross-matching ID
PubChem CID
5281034
ChEBI ID
CHEBI:7864
CAS Number
CAS 434-07-1
TTD Drug ID
DMFXUT8
INTEDE Drug ID
DR1225

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Steroid 5-alpha-reductase 1 (SRD5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone cypionate DMC1TEV N. A. N. A. Approved [6]
Testosterone enanthate DMB6871 N. A. N. A. Approved [6]
Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [8]
Testosterone DM7HUNW Hot flushes GA30 Approved [9]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [9]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [10]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [13]
Ethanol DMDRQZU Chronic pain MG30 Approved [14]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [16]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [19]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [20]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [21]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [23]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thyroid peroxidase (TPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [25]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [29]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [30]
Testosterone DM7HUNW Hot flushes GA30 Approved [31]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-7 (IL7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [34]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ethanol DMDRQZU Chronic pain MG30 Approved [35]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [38]
Isoproterenol DMK7MEY Atrioventricular block Approved [39]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kit ligand (KITLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Steroid 5-alpha-reductase 1 (SRD5A1) Main DME DEOG15F S5A1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [4]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [5]
Interleukin-7 (IL7) OTT6YSKM IL7_HUMAN Gene/Protein Processing [5]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Gene/Protein Processing [5]
Thyroid peroxidase (TPO) OTJJLL20 PERT_HUMAN Gene/Protein Processing [5]

References

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2 Oxymetholone FDA Label
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32 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
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41 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
42 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
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