Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFXUT8)

• Drug Name: Oxymetholone Drug Info
• Synonyms: oxymetholone; Anasterone; 434-07-1; HMS3393H15

Indication

Disease Entry	ICD 11	Status	REF
Aplastic anemia	3A70	Approved	[1]
Aregenerative anemia		Approved	[2]
Diamond-Blackfan anemia		Approved	[2]

• Cross-matching ID:
  PubChem CID: 5281034
  ChEBI ID: CHEMBL7864
  CAS Number: CAS 434-07-1
  TTD Drug ID: DMFXUT8
  INTEDE Drug ID: DR1225

Molecule-Related Drug Atlas

Drug(s) Metabolized By Steroid 5-alpha-reductase 1 (SRD5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[5]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[5]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[13]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Steroid 5-alpha-reductase 1 (SRD5A1) Main DME	DEOG15F	S5A1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Kit ligand (KITLG)	OTB9AVQ4	SCF_HUMAN	Gene/Protein Processing	[4]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Oxymetholone FDA Label
• [3] Androgen physiology. Semin Reprod Med. 2006 Apr;24(2):71-7.
• [4] Direct and indirect effects of androgens on survival of hematopoietic progenitor cells in vitro. J Korean Med Sci. 2005 Jun;20(3):409-16. doi: 10.3346/jkms.2005.20.3.409.
• [5] Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11).
• [6] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [7] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [8] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [9] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [10] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [11] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [12] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [13] How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
• [14] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [15] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.