Details of the Drug-Related molecule(s) Interaction Atlas

Dihydrolanosterol Drug Info

Dihydrolanosterin; Dihydrolanosterol; Lanost-8-en-3-ol; Lanost-8-en-3-ol #; Lanost-8-en-3-ol, (3.beta.)-; Lanost-8-en-3.beta.-ol; Lanost-8-en-3beta-ol; Lanostenol; Lanosterol, dihydro-; MBZYKEVPFYHDOH-BQNIITSRSA-N; SCHEMBL288306; (3beta)-Lanost-8-en-3-ol; 24,25-Dihydrolanosterol; 24-dihydrolanosterol; 3beta-Hydroxylanost-8-ene; 5alpha-Lanost-8-en-3 beta-ol; 5alpha-Lanost-8-en-3beta-ol; 79-62-9; 9H273A8B2X; CHEBI:28113; CHEMBL4213010; DTXSID101000181; UNII-9H273A8B2X

Cross-matching ID

PubChem CID

440560

ChEBI ID

CHEMBL28113

CAS Number

CAS 79-62-9

TTD Drug ID

DMG0PXI

INTEDE Drug ID

DR2224

General Information of Drug (ID: DMG0PXI)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Investigative Drug(s)

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Drug(s) Metabolized By Cytochrome P450 51B1 (cyp51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lanosterol	DMHN74V	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Metabolized By Cytochrome P450 monooxygenase 51A (cyp51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lanosterol	DMHN74V	Discovery agent	N.A.	Investigative	[1]
Obtusifoldienol	DMA63FQ	N. A.	N. A.	Investigative	[1] , [2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 monooxygenase 51A (cyp51A)	DEVSF75	CP51A_ASPFU	Substrate	[1] , [2]
Cytochrome P450 51B1 (cyp51)	DEZNP5G	B2HH81_MYCMM	Substrate	[3]

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References

1	The fungal CYP51s: their functions, structures, related drug resistance, and inhibitors. Front Microbiol. 2019 Apr 24;10:691.
2	Lung colonization by Aspergillus fumigatus is controlled by ZNF77. Nat Commun. 2018 Sep 20;9(1):3835.
3	Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.