Details of the Drug-Related molecule(s) Interaction Atlas

US10030004, Compound 11a Drug Info

SCHEMBL18205771; BDBM280344; US10030004, Compound 11a; Synthesis of (S)-4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-4-ylamino)-N-(2-hydroxy propyl)nicotinamide

Cross-matching ID

PubChem CID

91820701

TTD Drug ID

DMG4T13

General Information of Drug (ID: DMG4T13)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Activin receptor type IB (ACVR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9682983, 1	DM6EQVT	N. A.	N. A.	Patented	[2]
BDBM108945	DMZD6IJ	N. A.	N. A.	Patented	[2]
US10030004, Compound 19	DM0RAPC	N. A.	N. A.	Patented	[1]
US9682983, 33	DM6R1YP	N. A.	N. A.	Patented	[2]
US10030004, Compound 33	DMD0GN6	N. A.	N. A.	Patented	[1]
PMID23639540C13d	DMSTQGH	Discovery agent	N.A.	Investigative	[3]
PMID23639540C13r	DMHBZ0N	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Activin receptor type IB (ACVR1B)	TTPKHTZ	ACV1B_HUMAN	Inhibitor	[1]

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References

1	Compounds and methods of use. US10030004.
2	BMP inhibitors and methods of use thereof. US9682983.
3	Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.