Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG9HIA)

Drug Name

Urofollitropin Drug Info

Synonyms

Bravelle; Fertinex; Metrodin; Urofollitrophin; Fertinorm HP; Bravelle (TN); Fertinex (TN); Follistim (TN); Gonal-F(TN); (4-Threonine)oxytocin; 1,2-Dithia-5,8,11,14,17-penaazacycloeicosane, cyclic peptide deriv.; 4-(L-Threonine)oxytocin

Indication

Disease Entry	ICD 11	Status	REF
Female infertility	GA31.Z	Approved	[1]

Therapeutic Class

Fertility Agents

Cross-matching ID

PubChem CID: 62819
TTD Drug ID: DMG9HIA
ACDINA Drug ID: D01515

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Follicle-stimulating hormone receptor (FSHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menotropins	DM4CF18	Female infertility	GA31.Z	Approved	[3]
Follitropin beta	DM2JTS5	Female infertility	GA31.Z	Approved	[4]
Suramin	DMTOUY9	African trypanosomiasis	1F51	Phase 1	[5]
Recombinant follicle stimulating hormone	DMNHOI3	Female infertility	GA31.Z	Investigative	[6]
PRX-111	DMSPH30	Female infertility	GA31.Z	Investigative	[7]
Long-acting FSH conjugate	DMD32IN	Female infertility	GA31.Z	Investigative	[6]
FSHR NAM	DMPRMOD	Contraception	QA21	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Follicle-stimulating hormone receptor (FSHR)	TTZFDBT	FSHR_HUMAN	Binder	[2]

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References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	Follicle-stimulating hormone in clinical practice: an update. Treat Endocrinol. 2004;3(3):161-71.
3	The role of gonadotropins in ovulation induction. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 2):759-65.
4	Follitropin-alpha (Gonal-F) versus follitropin-beta (Puregon) in controlled ovarian hyperstimulation for in vitro fertilization: is there any diffe... Fertil Steril. 2009 Apr;91(4 Suppl):1522-5.
5	Suramin: clinical uses and structure-activity relationships. Mini Rev Med Chem. 2008 Nov;8(13):1384-94.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 253).
7	A naturally occurring basically charged human follicle-stimulating hormone (FSH) variant inhibits FSH-induced androgen aromatization and tissue-type plasminogen activator enzyme activity in vitro. Neuroendocrinology. 1998 Mar;67(3):153-63.