Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGCVT2)

Drug Name
9-anthroic acid Drug Info
Synonyms anthracene-10-carboxylic acid; 9-AC
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2201
ChEBI ID
CHEMBL34507
CAS Number
CAS 723-62-6
TTD Drug ID
DMGCVT2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Calcium-dependent chloride channel anoctamin (ANO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzbromarone DMC3YUA Gout FA25 Approved [6]
Crofelemer DM4AMQZ HIV-associated diarrhoea 1A2Z Approved [7]
NPPB DMFIWAN Discovery agent N.A. Investigative [2]
DIDS DMKSQUB Discovery agent N.A. Investigative [2]
SITS DMCMIUG Discovery agent N.A. Investigative [2]
DCDPC DMG9BFR Discovery agent N.A. Investigative [2]
tannic acid DM52WGH Discovery agent N.A. Investigative [2]
Ins(3,4,5,6)P4 DMAQU71 Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Targeting Volume regulated chloride channel (VRAC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NPPB DMFIWAN Discovery agent N.A. Investigative [4]
DIDS DMKSQUB Discovery agent N.A. Investigative [4]
GTPgammaS DMJUXKY Discovery agent N.A. Investigative [4]
1,9-dideoxyforskolin DMW613U Discovery agent N.A. Investigative [4]
diBA-(5)-C4 DM9KPHZ Discovery agent N.A. Investigative [4]
IAA-94 DMFSAK3 Discovery agent N.A. Investigative [4]
DCPIB DM9NMIY Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting Chloride channel protein 1 (ClC-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
S-(-)CPP DME9QR0 Discovery agent N.A. Investigative [3]
S-(-)CPB DMXUBIK Discovery agent N.A. Investigative [3]
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [8]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [9]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [10]
Diazepam DM08E9O Alcohol withdrawal Approved [11]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [12]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [13]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [14]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcium-dependent chloride channel anoctamin (ANO) TTOJI4S ANO1_HUMAN Blocker (channel blocker) [2]
Chloride channel protein 1 (ClC-1) TTUYAF3 CLCN1_HUMAN Blocker (channel blocker) [3]
Volume regulated chloride channel (VRAC) TT0FC1V NOUNIPROTAC Blocker (channel blocker) [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [5]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4113).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 698).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710).
5 Interaction of anthracene and its oxidative derivatives with human serum albumin. Acta Biochim Pol. 2006;53(1):101-12. Epub 2006 Jan 9.
6 Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis.Reprod Sci. 2018 Nov;25(11):1589-1600.
7 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
8 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
9 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
10 A protein-coated magnetic beads as a tool for the rapid drug-protein binding study. J Pharm Biomed Anal. 2010 Jul 8;52(3):420-4. doi: 10.1016/j.jpba.2009.06.023. Epub 2009 Jun 18.
11 The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties. J Biol Chem. 1999 Oct 8;274(41):29303-10. doi: 10.1074/jbc.274.41.29303.
12 Exploring binding properties of sertraline with human serum albumin: Combination of spectroscopic and molecular modeling studies. Chem Biol Interact. 2015 Dec 5;242:235-46. doi: 10.1016/j.cbi.2015.10.006. Epub 2015 Oct 22.
13 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
14 Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates. J Chromatogr A. 2011 Apr 15;1218(15):2072-8. doi: 10.1016/j.chroma.2010.09.070. Epub 2010 Oct 16.
15 [Colchicine in chronic liver disease of alcoholic etiology. Double-blind, randomized study of its effects on blood levels of plasma proteins and clinical course in patients]. Rev Assoc Med Bras (1992). 1995 May-Jun;41(3):207-12.
16 Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
17 Covalent binding of the flavonoid quercetin to human serum albumin. J Agric Food Chem. 2005 May 18;53(10):4194-7. doi: 10.1021/jf050061m.