Details of the Drug-Related molecule(s) Interaction Atlas

US8546370, 17 Drug Info

SCHEMBL1048459; CHEMBL3642578; BDBM103511; US8546370, 17

Cross-matching ID

PubChem CID

44180013

TTD Drug ID

DMGIJZA

General Information of Drug (ID: DMGIJZA)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Tyrosine-protein kinase ZAP-70 (ZAP-70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8546370, 102	DMQRO6G	N. A.	N. A.	Patented	[1]
US8546370, 11	DM2K6YU	N. A.	N. A.	Patented	[1]
aloisine	DM7HGX8	Discovery agent	N.A.	Investigative	[2]
K00592a	DM1RP5Q	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine-protein kinase ZAP-70 (ZAP-70)	TTUMHT8	ZAP70_HUMAN	Inhibitor	[1]

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References

1	Compounds and compositions as kinase inhibitors. US8546370.
2	Identification of binding specificity-determining features in protein families. J Med Chem. 2012 Mar 8;55(5):1926-39.
3	Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51.