Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGSDPL)

Drug Name

NK-314 Drug Info

Synonyms

Topoisomerase modulator, Nippon Kayaku

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting DNA topoisomerase II (TOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[3]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[4]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[5]
Idarubicin	DMM0XGL	Acute myelogenous leukaemia	2A41	Approved	[3]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Lomefloxacin	DMVRH9C	Bacterial infection	1A00-1C4Z	Approved	[6]
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[3]
Podofilox	DMT2EJP	Condyloma	1A95	Approved	[7]
Enoxacin	DMYTE6L	Acute gonococcal cervicitis		Approved	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020174)
2	NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem. 2008 Aug 29;283(35):23711-20.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72.
5	Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
6	Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22.
7	Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000 Dec;6(18):1811-39.
8	Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clin Pharmacokinet. 1988 Feb;14(2):96-121.