Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHBWOP)

Drug Name

JT07 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting C-X-C chemokine receptor type 7 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GW-766994	DMKC0J5	Asthma	CA23	Discontinued in Phase 2	[2]
CCX-662	DM6WX1A	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]
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Drug(s) Targeting C-X-C chemokine receptor type 3 (CXCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
T487	DMZTL7H	Psoriatic disorder	EA90	Discontinued in Phase 2	[4]
dioscin	DM5H2W9	Hepatic fibrosis	DB93.0	Preclinical	[5]
kallstroemin D	DM7YAE0	Discovery agent	N.A.	Investigative	[5]
NBI-74330	DMURC6X	Discovery agent	N.A.	Investigative	[4]
Sch-900875	DM346KA	Inflammation	1A00-CA43.1	Investigative	[6]
hypoglaucin A	DMJKIUX	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-X-C chemokine receptor type 3 (CXCR3)	TT1UCIJ	CXCR3_HUMAN	Inhibitor	[1]
C-X-C chemokine receptor type 7 (ACKR3)	TTRQJTC	ACKR3_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of Jyant Technologies.
2	Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 80).
4	Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71.
5	Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. Mol Divers. 2005;9(1-3):123-9.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 70).