Details of the Drug-Related molecule(s) Interaction Atlas

D-carnitine Drug Info

(+)-Carnitine; (3S)-3-hydroxy-4-(trimethylammonio)butanoate; (3S)-3-hydroxy-4-(trimethylazaniumyl)butanoate; (S)-3-Hydroxy-4-(trimethylammonio)butanoate; CHEBI:11060; Carnitine D-form; D-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide, inner salt; D-carnitine; U9VY0ZOK7A; UNII-U9VY0ZOK7A

Cross-matching ID

PubChem CID

2724480

ChEBI ID

ChEBI:11060

CAS Number

CAS 541-14-0

TTD Drug ID

DMHNAJ7

VARIDT Drug ID

DR00350

General Information of Drug (ID: DMHNAJ7)

Molecule-Related Drug Atlas

Molecule Type:

DTP

Drug Status:

Approved Drug(s)

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Drug(s) Transported By Organic cation/carnitine transporter 2 (SLC22A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[2]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[3]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[4]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[5]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[6]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[7]
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[8]
Ipratropium	DMFQ320	Obstructive lung disease	CA22.Z	Approved	[8]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[9]
Acetylcarnitine	DM4UE3K	Chronic fatigue syndrome	8E49	Phase 4	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation/carnitine transporter 2 (SLC22A5)	DT3HUVD	S22A5_HUMAN	Substrate	[1]

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References

1	Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. Am J Physiol Renal Physiol. 2000 Sep;279(3):F584-91.
2	Genetic variations of the SLC22A5 gene in the Chinese and Indian populations of Singapore. Drug Metab Pharmacokinet. 2010;25(1):112-9.
3	Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84.
4	Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
5	Colistin is substrate of the carnitine/organic cation transporter 2 (OCTN2, SLC22A5). Drug Metab Dispos. 2017 Dec;45(12):1240-1244.
6	Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. J Pharmacol Exp Ther. 2005 Jan;312(1):192-8.
7	Mutations affecting GABAergic signaling in seizures and epilepsy. Pflugers Arch. 2010 Jul;460(2):505-23.
8	Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95.
9	Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice. Biopharm Drug Dispos. 2009 Dec;30(9):495-507.
10	Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2. Arch Biochem Biophys. 2006 Aug 1;452(1):29-37.