Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHX4F2)

Drug Name

N-(4'-t-butyl-4-biphenylyl)urea Drug Info

Synonyms

CHEMBL244126; SCHEMBL5425660; N-(4''-t-butyl-4-biphenylyl)urea; BDBM50220188

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Kinesin spindle messenger RNA (KIF11 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALN-VSP	DM89DHO	Liver cancer	2C12	Phase 1	[2]
EMD-534085	DMQ6YAZ	Haematological malignancy	2B33.Y	Phase 1	[3]
N-[4'-(trifluoromethyl)-4-biphenylyl]thiourea	DMPVKWG	Discovery agent	N.A.	Investigative	[1]
N-[3'-(trifluoromethyl)-4-biphenylyl]urea	DM7OA4R	Discovery agent	N.A.	Investigative	[1]
4'-(trifluoromethyl)-4-biphenylsulfonamide	DMLP67R	Discovery agent	N.A.	Investigative	[1]
N-(4'-chloro-4-biphenylyl)methanesulfonamide	DM0ARP8	Discovery agent	N.A.	Investigative	[1]
ISIS 183881	DMOU9EP	Discovery agent	N.A.	Investigative	[4]
ISIS 183911	DMTB350	Discovery agent	N.A.	Investigative	[5]
4'-(trifluoromethyl)-4-biphenylyl carbamate	DMT3BX9	Discovery agent	N.A.	Investigative	[1]
ISIS 183910	DMMQ2L7	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kinesin spindle messenger RNA (KIF11 mRNA)	TTBGTCW	KIF11_HUMAN	Inhibitor	[1]

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References

1	Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52.
2	Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011).
3	The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5.
4	US patent application no. 7,407,943, Antisense modulation of apolipoprotein B expression.
5	US patent application no. 7,163,927, Antisense modulation of kinesin-like 1 expression.