Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI0H3B)

Drug Name

UshStat Drug Info

Synonyms

Myosin 7A gene therapy (Usher syndrome 1B, LentiVector), Oxford BioMedica; Myosin VIIA gene therapy (Usher syndrome 1B, LentiVector), Oxford BioMedica

Indication

Disease Entry	ICD 11	Status	REF
Deafness	AB52	Phase 1/2	[1]
Retinitis pigmentosa	9B70	Phase 1	[2]

Cross-matching ID

TTD Drug ID: DMI0H3B

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Myosin-7 (MYH7)	TTNIMDP	MYH7_HUMAN	Modulator	[3]

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References

1	ClinicalTrials.gov (NCT02065011) A Study to Determine the Long-Term Safety, Tolerability and Biological Activity of UshStat in Patients With Usher Syndrome Type 1B. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: development of UshStat. PLoS One. 2014 Apr 4;9(4):e94272.