Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI7DZ2)

Drug Name

Prilocaine Drug Info

Synonyms

Citanest; Prilocaina; Prilocainum; Propitocaine; Prilocaine [USAN]; Prilocaine base; Astra 1512; Astra 1515; L 67; Citanest (TN); Prilocaina [INN-Spanish]; Prilocainum [INN-Latin]; Propitocaine (JAN); Prilocaine (USP/INN); O-Methyl-2-propylaminopropionanilide; O-Methyl-alpha-propylaminopropionanilide; Alpha-n-Propylamino-2-methylpropionanilide; N-[2-Methylphenyl]-2-[propylamino]propanamide; N-(2-methylphenyl)-N2-propylalaninamide; N-(2-Methylphenyl)-2-(propylamino)propanamide; N-(2-methylphenyl)-N(2)-propylalaninamide; Propanamide, N-(2-methylphenyl)-2-(propylamino)-(9CI); 2-(Propylamino)-o-propionotoluidide; 2-Methyl-.alpha.-propylaminopropionanilide; 2-Methyl-alpha-propylaminopropionanilide

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Approved	[1]
Premature ejaculation	HA03.0Z	Investigative	[2]

Therapeutic Class

Anesthetics

Cross-matching ID

PubChem CID: 4906
ChEBI ID: CHEMBL1194
CAS Number: CAS 721-50-6
TTD Drug ID: DMI7DZ2

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.5 (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mephenytoin	DM5UGDK	Epilepsy	8A60-8A68	Approved	[4]
Mexiletine	DMCTE9R	Ventricular tachycardia	BC71	Approved	[5]
Fosphenytoin	DMOX3LB	Epilepsy	8A60-8A68	Approved	[4]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[5]
LOMERIZINE	DME0TC8	Migraine	8A80	Approved	[6]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[7]
Dyclonine	DMU6OFP	Pain	MG30-MG3Z	Approved	[3]
Moricizine	DMOMBJW	Arrhythmia	BC9Z	Approved	[8]
Ethotoin	DMXWOCP	Complex partial seizure	8A68.0	Approved	[9]
Hexylcaine	DMEADRK	Anaesthesia	9A78.6	Approved	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.5 (SCN5A)	TTZOVE0	SCN5A_HUMAN	Blocker	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7276).
2	Prilocaine FDA Label
3	Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12.
4	Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68.
5	Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9.
6	Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37.
7	Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81.
8	From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33.
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.