Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIAQUC)

Drug Name

6-p-Tolylamino-1H-pyrimidine-2,4-dione Drug Info

Synonyms

CHEMBL57397; 6-p-Tolylamino-1H-pyrimidine-2,4-dione; 6948-11-4; 6-[(4-methylphenyl)amino]pyrimidine-2,4(1h,3h)-dione; NSC55724; AC1Q6LTF; CBMicro_020485; Oprea1_316803; Oprea1_212741; SCHEMBL5298937; AC1L6E57; CTK5D0097; 2,4(1H,3H)-Pyrimidinedione, 6-[(4-methylphenyl)amino]-; MolPort-003-722-204; ZINC227430; CCG-8301; NSC-55724; BDBM50022161; AKOS001620102; MCULE-6764538026; BIM-0020481.P001; EU-0034750; SR-01000400155; SR-01000400155-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 244640
CAS Number: CAS 6948-11-4
TTD Drug ID: DMIAQUC

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting DNA topoisomerase (TOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[2]
Icofungipen	DMTXNZK	Fungal infection	1F29-1F2F	Phase 2	[3]
TOPOSTATIN	DMNZQO9	Discovery agent	N.A.	Investigative	[4]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione	DMKUHN9	Discovery agent	N.A.	Investigative	[1]
N4-Benzyl-6-chloro-pyrimidine-2,4-diamine	DMNGSQK	Discovery agent	N.A.	Investigative	[5]
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione	DMTPRIW	Discovery agent	N.A.	Investigative	[5]
6-Benzylamino-1H-pyrimidine-2,4-dione	DM8FUZL	Discovery agent	N.A.	Investigative	[5]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione	DMMFWYX	Discovery agent	N.A.	Investigative	[1]
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione	DMSH107	Discovery agent	N.A.	Investigative	[1]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione	DMGJYWF	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase (TOP)	TT2GPK3	NOUNIPROTAC	Inhibitor	[1]

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References

1	Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9.
4	Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7.
5	Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81.