Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIDP1R)

Drug Name

peptide 18 Drug Info

Synonyms

Ac-LLLLRVK-Amba

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Patented Agent(s)

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Proprotein convertase subtilisin/kexin type 7 (PCSK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
furin inhibitor peptide	DM78NOM	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Dibasic-processing enzyme (Furin)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9266828, E	DMYUL2X	N. A.	N. A.	Patented	[3]
US9266828, C	DMQEL1W	N. A.	N. A.	Patented	[3]
US9266828, B	DMYUDCE	N. A.	N. A.	Patented	[3]
DecRVKRCMK	DMAUILH	Coronavirus infection	1D92	Preclinical	[4]
furin inhibitor peptide	DM78NOM	Discovery agent	N.A.	Investigative	[2]
MI-1148	DMCN91V	Discovery agent	N.A.	Investigative	[5]
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⏷ Show the Full List of 6 Drug(s)

Drug(s) Targeting Proprotein convertase subtilisin/kexin type 6 (PCSK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
furin inhibitor peptide	DM78NOM	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Neuroendocrine convertase 2 (PCSK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide	DM16KSA	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dibasic-processing enzyme (Furin)	TTH9WF6	FURIN_HUMAN	Inhibitor	[1]
Neuroendocrine convertase 2 (PCSK2)	TT46F0P	NEC2_HUMAN	Inhibitor	[1]
Proprotein convertase subtilisin/kexin type 6 (PCSK6)	TT75LN9	PCSK6_HUMAN	Inhibitor	[1]
Proprotein convertase subtilisin/kexin type 7 (PCSK7)	TTD30LY	PCSK7_HUMAN	Inhibitor	[1]

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References

1	Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109.
2	Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53.
3	Inhibitors of Furin and other pro-protein convertases. US9266828.
4	Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses. 2019 Oct 31;11(11):1011.
5	Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem. 2015 Jul;10(7):1218-31.
6	Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem. 2010 Feb 11;53(3):1067-75.