Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIE039)

• Drug Name: SC-47643 Drug Info
• Synonyms: CHEMBL129921; BDBM50035970; 3-(8-Guanidino-octanoylamino)-N-[2-(4-methoxy-phenyl)-ethyl]-succinamic acid
• Cross-matching ID:
  PubChem CID: 124392
  CAS Number: CAS 126631-86-5
  TTD Drug ID: DMIE039

Molecule-Related Drug Atlas

Drug(s) Targeting ITGB3 messenger RNA (ITGB3 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
XEMILOFIBAN	DMBRYT8	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 3	[2]
DMP-802	DMDK6HP	N. A.	N. A.	Discontinued in Phase 1	[3]
SB-223245	DM3JQCF	N. A.	N. A.	Terminated	[4]
L-709780	DMB3ZTI	N. A.	N. A.	Terminated	[5]
Ro-43-8857	DM4VY8S	N. A.	N. A.	Terminated	[3]
SKF-107260	DMM8F0V	N. A.	N. A.	Terminated	[6]
L-738167	DMO69X8	N. A.	N. A.	Terminated	[3]
DMP-757	DMGNUXC	N. A.	N. A.	Terminated	[7]
Ro-43-5054	DMPNHF0	N. A.	N. A.	Terminated	[3]
C(-GRGDfL-)	DMTMJAI	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Proteinase activated receptor 4 (F2RL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate	DM5GLP7	Discovery agent	N.A.	Investigative	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ITGB3 messenger RNA (ITGB3 mRNA)	TTJA1ZO	ITB3_HUMAN	Inhibitor	[1]
Proteinase activated receptor 4 (F2RL3)	TTD0652	PAR4_HUMAN	Inhibitor	[1]

References

• [1] Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation. J Med Chem. 1995 Jan 6;38(1):34-41.
• [2] Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308. J Med Chem. 1999 Dec 16;42(25):5254-65.
• [3] Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73.
• [4] Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a resten... Bioorg Med Chem Lett. 1998 Nov 17;8(22):3171-6.
• [5] Non-peptide fibrinogen receptor antagonists. 3. design and discovery of a centrally constrained inhibitorc, Bioorg. Med. Chem. Lett. 4(15):1835-1840 (1994).
• [6] Preparation and Properties of a fibrinogen receptor antagonist containing the Arg-Gly-Asp sequence and nitroxide radicals, Bioorg. Med. Chem. Lett. 3(6):1179-1184 (1993).
• [7] Synthesis and antiplatelet activity of DMP 757 analogs, Bioorg. Med. Chem. Lett. 5(18):2097-2100 (1995).
• [8] Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81.
• [9] Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives. Bioorg Med Chem. 2008 Feb 1;16(3):1262-78.