Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ108U)

Drug Name

LJP-1207 Drug Info

Synonyms

LJP-1200; LJP-1233; LJP-1586; SSAO inhibitors (inflammation); SSAO inhibitors, La Jolla; VAP-1 inhibitors, La Jolla; Vascular adhesion protein-1 inhibitors, La Jolla; Semi-carbazide-sensitive amine oxidase, La Jolla

Indication

Disease Entry	ICD 11	Status	REF
Cerebrovascular ischaemia	8B1Z	Investigative	[1]

Cross-matching ID

PubChem CID: 11615193
TTD Drug ID: DMJ108U

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Membrane copper amine oxidase (AOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[2]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[3]
ASP8232	DMYK1JU	Diabetic macular edema	9B71.02	Phase 2	[4]
BTT-1023	DMIEPJG	Psoriasis vulgaris	EA90	Phase 2	[5]
BI 1467335	DMTE3UV	Diabetic retinopathy	9B71.0	Discontinued in Phase 2	[6]
Vapaliximab	DM73EPK	Inflammation	1A00-CA43.1	Terminated	[7]
Vapill	DM30E56	Diabetic complication	5A2Y	Investigative	[1]
PSX-4206	DMVJDCM	Pulmonary disease	1B10-1F85	Investigative	[1]
RTU-1096	DMWVBD9	Atopic dermatitis	EA80	Investigative	[1]
FP-1102	DMGID4T	Vascular disease	BE2Z	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Membrane copper amine oxidase (AOC3)	TT7HC21	AOC3_HUMAN	Inhibitor	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767).
2	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Preclinical evaluation of a radioiodinated fully human antibody for in vivo imaging of vascular adhesion protein-1-positive vasculature in inflammation. J Nucl Med. 2013 Aug;54(8):1315-9.
6	Clinical pipeline report, company report or official report of Boehringer Ingelheim.
7	Clinical pipeline report, company report or official report of Huginonline.