Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ4SDM)

Drug Name

3-chlorotyrosine Drug Info

Synonyms

Monochlorotyrosine; Tyrosine, 3-chloro-; 3-Chloro-DL-tyrosine; C9H10ClNO3; 2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; 7298-90-0; AC1L3OFH; AC1Q3M6L; SCHEMBL157442; L-(8CI)-3-chloro-Tyrosine; GTPL5114; CTK7I4440; ACWBBAGYTKWBCD-UHFFFAOYSA-N; AKOS009158821; VZ26714; MCULE-5698335509; KB-31251; LS-177012; A838069; 2-azanyl-3-(3-chloranyl-4-oxidanyl-phenyl)propanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 110992
ChEBI ID: CHEBI:53678
CAS Number: CAS 7423-93-0
TTD Drug ID: DMJ4SDM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[3]
L-Tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[4]
Tetrahydrobiopterin	DMINZ4W	Malnutrition	5B50-5B71	Approved	[5]
Metyrosine	DMBYCU0	Pheochromocytoma	5A75	Approved	[6]
L1-79	DMLHPVW	Autism spectrum disorder	6A02	Phase 2	[7]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[8]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[9]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[10]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[2]
Meta-Tyrosine	DM0748C	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine 3-monooxygenase (TH)	TTUHP71	TY3H_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5114).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).
3	Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
4	Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
5	Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
6	Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8.
7	Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981.
8	Clinical pipeline report, company report or official report of Oxford BioMedica.
9	Clinical pipeline report, company report or official report of Oxford BioMedica.
10	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.