Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJDT5O)

Drug Name
VIS513 Drug Info
Indication
Disease Entry ICD 11 Status REF
Dengue 1D20-1D2Z Preclinical [1]
Cross-matching ID
TTD Drug ID
DMJDT5O

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dengue virus Envelope (DENV E) TTMYZNX POLG_DEN1W (281-775) Inhibitor [2]

References

1 Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates. Antiviral Res. 2017 Aug;144:44-47.
2 Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein. PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006209.