Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJRK47)

Drug Name

M-Phenoxybenzoic Acid For Cis-Isomer Drug Info

Synonyms

3-Phenoxybenzoic acid; 3739-38-6; m-Phenoxybenzoic acid; Benzoic acid, 3-phenoxy-; 3-Carboxydiphenyl ether; UNII-69DC2655VH; BENZOIC ACID, m-PHENOXY-; 3-Phenoxy-benzoic acid; EINECS 223-121-2; CHEMBL663; BRN 2105574; M-PHENOXYBENZOIC ACID FOR CIS-ISOMER; CHEBI:72631; NXTDJHZGHOFSQG-UHFFFAOYSA-N; 69DC2655VH; VJJ; 3-Phenoxybenzoicacid; m-phenoxy benzoic acid; m-carboxydiphenyl ether; PubChem14424; 3-phenoxy benzoic acid; meta-phenoxybenzoic acid; ACMC-1CJQX; Enamine_000396; AC1L2EBV; Benzoic acid,3-phenoxy-; 3-PhOC6H4COOH

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 19539
ChEBI ID: CHEMBL72631
CAS Number: CAS 3739-38-6
TTD Drug ID: DMJRK47

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Dihydrodiol dehydrogenase type I (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[4]
ASP-9521	DM8V0UL	Prostate cancer	2C82.0	Phase 1/2	[5]
N-(benzimidazole/indole) benzoic acid derivative 2	DMOPUFM	N. A.	N. A.	Patented	[6]
N-(phenylamino)-benzoate derivative 1	DMNIWVG	N. A.	N. A.	Patented	[6]
Indomethacin analog 3	DM53JXE	N. A.	N. A.	Patented	[6]
Indomethacin analog 2	DMKFPJ7	N. A.	N. A.	Patented	[6]
Beta-naphthylacetic acids derivative 1	DM5KTDY	N. A.	N. A.	Patented	[6]
Indomethacin analog 1	DM3E5V6	N. A.	N. A.	Patented	[6]
N-(naphthylamino)-benzoate derivative 1	DM310ES	N. A.	N. A.	Patented	[6]
N-(benzimidazolylcarbonyl)-piperidine derivative 1	DM541QW	N. A.	N. A.	Patented	[6]
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Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[7]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[11]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[8]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[8]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydrodiol dehydrogenase type I (AKR1C3)	TT5ZWB6	AK1C3_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome P450 4A11 (CYP4A11)	OTPU5J0S	CP4AB_HUMAN	Gene/Protein Processing	[2]
Vitamin D3 receptor	OTFC7K35	VDR_HUMAN	Protein Interaction/Cellular Processes	[3]

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References

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2	An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. Toxicol Sci. 2020 May 1;175(1):50-63. doi: 10.1093/toxsci/kfaa017.
3	Structure-based Identification of Endocrine Disrupting Pesticides Targeting Breast Cancer Proteins. Toxicology. 2020 Jun;439:152459. doi: 10.1016/j.tox.2020.152459. Epub 2020 Apr 9.
4	Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51.
5	Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Invest New Drugs. 2014 Oct;32(5):995-1004.
6	Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340.
7	Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. Toxicol In Vitro. 2009 Oct;23(7):1259-67.
8	Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
9	The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
10	Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
11	Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.