Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJTGZV)

Drug Name

Alpha-monofluoromethyl-3,4-dehydroornithine ethyl ester Drug Info

Synonyms

Mdl-72430; 2-(Fluoromethyl)dehydroornithine ethyl ester; AC1O5Q9S; SCHEMBL10981099; 97501-15-0; ethyl (E)-2,5-diamino-2-(fluoromethyl)pent-3-enoate; 3-Pentenoic acid, 2,5-diamino-2-(fluoromethyl)-, ethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6438751
CAS Number: CAS 97501-15-0
TTD Drug ID: DMJTGZV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eflornithine	DMJOQM3	African trypanosomiasis	1F51	Approved	[1]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[2]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[2]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[2]
Pyridoxine-5'-Phosphate	DMFUNL1	Discovery agent	N.A.	Investigative	[2]
APA	DMVG3K1	Discovery agent	N.A.	Investigative	[3]
AMXT-1501	DMPSRZ0	Head and neck cancer	2D42	Investigative	[4]
(2R,5R)-delta-methyl-alpha-acetylenic putrescine	DMSFXEO	Discovery agent	N.A.	Investigative	[1]
ZAPOTIN	DMM4ZKU	Discovery agent	N.A.	Investigative	[5]
LONCHOCARPUSONE	DMWFAPJ	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[1]

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References

1	Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276).
5	Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.
6	New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.