Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJY2TM)

• Drug Name: Gabapentin enacarbil Drug Info
• Synonyms: 1838262; ASP8825; Gabapentin-XP; GSK 1838262; Horizant; Regnite; Solzira; XP13512

Indication

Disease Entry	ICD 11	Status	REF
Postherpetic neuralgia	1E91.5	Approved	[1]
Alcohol dependence	6C40.2	Phase 2	[2]

• Therapeutic Class: Neurology Agents
• Cross-matching ID:
  PubChem CID: 9883933
  ChEBI ID: CHEBI:68840
  CAS Number: CAS 478296-72-9
  TTD Drug ID: DMJY2TM
  VARIDT Drug ID: DR00089

Molecule-Related Drug Atlas

Drug(s) Transported By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[6]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[7]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Gamma Hydroxybutyric Acid	DMGBKVD	Narcolepsy	7A20	Approved	[8]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[9]
Pyroglutamic Acid	DMROZUA	Discovery agent	N.A.	Investigative	[10]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[5]
Hydroxyacetic Acid	DMQFBH6	Discovery agent	N.A.	Investigative	[11]
biotin	DMKMCE1	Discovery agent	N.A.	Investigative	[12]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[13]

Drug(s) Transported By Sodium-coupled monocarboxylate transporter 1 (SLC5A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propionate	DM0O8N6	Discovery agent	N.A.	Investigative	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sodium-dependent multivitamin transporter (SLC5A6)	TT61XTV	SC5A6_HUMAN	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium-coupled monocarboxylate transporter 1 (SLC5A8)	DTE3TAW	SC5A8_HUMAN	Substrate	[4]
Sodium-dependent multivitamin transporter (SLC5A6)	DTD5Y4G	SC5A6_HUMAN	Substrate	[4]
Monocarboxylate transporter 1 (SLC16A1)	DT342ZG	MOT1_HUMAN	Substrate	[5]

References

• [1] Gabapentin enacarbil FDA Label
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507.
• [5] Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J. 2008 Jun;10(2):311-21.
• [6] Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action. Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):904-17.
• [7] H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol. 2007 Jul;92(4):603-19.
• [8] Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. Drug Metab Dispos. 2007 Feb;35(2):201-8.
• [9] AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010 Jan 15;425(3):523-30.
• [10] Interaction of atorvastatin with the human glial transporter SLC16A1. Eur J Pharmacol. 2016 Oct 5;788:248-254.
• [11] Cidofovir peptide conjugates as prodrugs. Journal of Organometallic Chemistry, 2005, 690(10):2673-2678.
• [12] Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46.
• [13] Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9.
• [14] SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. Biochem J. 2016 May 1;473(9):1113-24.