Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK07MI)

Drug Name

L-(cis)-diltiazem Drug Info

Synonyms

L-cis-diltiazem; CHEBI:82813; [(2R,3R)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate; L-(cis)-diltiazem; ent-diltiazem; cis-3-Acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one; (-)-cis-diltiazem; Lopac-D-2521; BSPBio_001357; SCHEMBL676914; GTPL2349; AC1L54N5; CHEMBL1397935; ZINC601259; HMS1791D19; HMS1989D19; NCGC00016818-04; NCGC00015332-01; NCGC00163133-03; NCGC00015332-02; NCGC00016818-01; CAS-33286-22-5; BRD-K81029756-001-02-8

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 198107
ChEBI ID: CHEBI:82813
CAS Number: CAS 56209-45-1
TTD Drug ID: DMK07MI

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cyclic nucleotide-gated channel beta-3 (CNGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AAV-CNGB3	DM0CJAN	Achromatopsia	9B70	Phase 1/2	[7]
ACHM-CNGB3	DMC4ZQD	Achromatopsia	9B70	Phase 1/2	[8]
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Drug(s) Targeting Cyclic nucleotide-gated channel alpha-2 (CNGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dequalinium	DMXM19W	Myelopathy	8B42	Clinical trial	[9]
all-trans-retinal	DM6CEVB	Discovery agent	N.A.	Investigative	[10]
PIP3	DMJX39N	Discovery agent	N.A.	Investigative	[11]
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Drug(s) Targeting Cyclic nucleotide-gated channel alpha-3 (CNGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACHM-CNGA3	DMIRGTZ	Achromatopsia	9B70	Phase 1/2	[8]
AAV-CNGA3	DMNZJAE	Achromatopsia	9B70	Phase 1/2	[7]
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Drug(s) Targeting Cyclic nucleotide-gated channel alpha-1 (CNGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dequalinium	DMXM19W	Myelopathy	8B42	Clinical trial	[12]
H-8	DM80QF9	Discovery agent	N.A.	Investigative	[13]
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Drug(s) Targeting Voltage-gated calcium channel alpha Cav1.4 (CACNA1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-(S)-BayK8644	DMEA9KH	Discovery agent	N.A.	Investigative	[14]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclic nucleotide-gated channel alpha-1 (CNGA1)	TTHIQMC	CNGA1_HUMAN	Blocker (channel blocker)	[2]
Cyclic nucleotide-gated channel alpha-2 (CNGA2)	TT8SJGB	CNGA2_HUMAN	Blocker (channel blocker)	[3]
Cyclic nucleotide-gated channel alpha-3 (CNGA3)	TTW0QOV	CNGA3_HUMAN	Inhibitor	[4]
Cyclic nucleotide-gated channel beta-3 (CNGB3)	TT0LJCG	CNGB3_HUMAN	Blocker (channel blocker)	[5]
Voltage-gated calcium channel alpha Cav1.4 (CACNA1F)	TTJ0SO4	CAC1F_HUMAN	Inhibitor (gating inhibitor)	[6]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2349).
2	A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22;362(6422):764-7.
3	Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 396).
5	Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32.
6	Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):708-13.
7	Clinical pipeline report, company report or official report of MeiraGTx.
8	Clinical pipeline report, company report or official report of Applied Genetic Technologies.
9	State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304.
10	All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8372-7.
11	Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15635-40.
12	Dequalinium: a novel, high-affinity blocker of CNGA1 channels. J Gen Physiol. 2003 Jan;121(1):37-47.
13	Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel alpha-subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor. Neurosci Lett. 1997 Sep 12;233(1):37-40.
14	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 531).