Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK0VFS)

Drug Name
dithiipin-1,1,4,4-tetroxide analogue 7 Drug Info
Synonyms dithiipin-1,1,4,4-tetroxide analogue 7; GTPL6124; CHEMBL3906195; 2-(4-methylphenyl)-6,7-dihydro-5H-1,4-dithiepine 1,1,4,4-tetraoxide; 2-(4-Methylphenyl)-6,7-dihydro-5H-1,4-dithiepin 1,1,4,4-tetraoxide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9947811
TTD Drug ID
DMK0VFS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Galanin receptor (GAL-R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HT-2157 DM7C1AJ Cognitive impairment 6D71 Phase 1/2 [3]
galmic DML9DH8 Discovery agent N.A. Investigative [4]
Sch 202596 DMRC4LE Discovery agent N.A. Investigative [5]
GalR3ant DMI7RPT Discovery agent N.A. Investigative [6]
CYM2503 DM5NFEA Discovery agent N.A. Investigative [7]
(E)-3-(4-chlorophenylimino)indolin-2-one DMPOYK2 Discovery agent N.A. Investigative [8]
SNAP 398299 DMS1AFL Discovery agent N.A. Investigative [3]
(E)-3-(2,3-dichlorophenylimino)indolin-2-one DM1LG27 Discovery agent N.A. Investigative [8]
2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide DMJB7W1 Discovery agent N.A. Investigative [2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Galanin receptor (GAL-R) TTOPAY7 GALR1_HUMAN; GALR2_HUMAN; GALR3_HUMAN Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6124).
2 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor. Bioorg Med Chem. 2000 Jun;8(6):1383-91.
3 Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94.
4 Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 245).
6 Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides. 2005 Jun;39(3):165-7.
7 GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15229-34.
8 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3757-8.