Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK12C0)

Drug Name

L-mannitol derivative Drug Info

Synonyms

CHEMBL410049; L-mannitol derivative; BDBM50173733

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Plasmodium Plasmepsin 1 (Malaria PLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pepstatin	DM9S1EA	Malaria	1F40-1F45	Terminated	[2]
Leupeptin	DMU075F	Malaria	1F40-1F45	Investigative	[2]
E-64	DMMOPAK	Discovery agent	N.A.	Investigative	[3]
KNI-10006	DMMISH6	Discovery agent	N.A.	Investigative	[4]
PS-777621	DM3F7SD	Discovery agent	N.A.	Investigative	[5]
SC-5003	DM2DU80	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Plasmepsin 1 (Malaria PLA1)	TTH9VL3	PLM1_PLAFA	Inhibitor	[1]

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References

1	Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. J Med Chem. 2005 Sep 22;48(19):6090-106.
2	Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
3	Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8.
4	alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem. 2009 Aug 15;17(16):5933-49.
5	High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9.
6	Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43(3):305-41.