Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKBILF)

Drug Name

UK-78282 Drug Info

Synonyms

UK-78282; CHEMBL9653; AC1LCVJE; UK 78282; UK-78282 monohydrochloride; CHEBI:35042; C13848; 4-(benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine; ZINC3798289; DNC004154; BDBM50098785; NCGC00370962-01; AJ-45641; RT-016190; J-006878

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Terminated	[1]

Cross-matching ID

PubChem CID: 656768
ChEBI ID: CHEBI:35042
TTD Drug ID: DMKBILF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Voltage-gated potassium channel Kv1.3 (KCNA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Debio-0824	DMV401D	Psoriasis vulgaris	EA90	Phase 1b/2a	[3]
Dalazatide	DMJ1NG4	Inclusion body myositis	4A41.2	Phase 1b/2a	[4]
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[5]
4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one	DMKMH5L	Discovery agent	N.A.	Investigative	[6]
2-Methoxy-N-(3-methyl-2-phenyl-butyl)-benzamide	DM31E6J	Discovery agent	N.A.	Investigative	[7]
correolide	DMACH7K	Discovery agent	N.A.	Investigative	[8]
Correloid	DM5ISQK	Discovery agent	N.A.	Investigative	[9]
CP-339818	DMTJOWH	Discovery agent	N.A.	Investigative	[2]
5-(4-Phenylbutoxy)psoralen	DM3QFCV	Discovery agent	N.A.	Investigative	[10]
[1-Benzyl-1H-quinolin-(4E)-ylidene]-hexyl-amine	DMH3BG5	Discovery agent	N.A.	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated potassium channel Kv1.3 (KCNA3)	TTY3UE6	KCNA3_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009179)
2	Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. J Med Chem. 2001 Apr 12;44(8):1249-56.
3	Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease. J Pharmacol Exp Ther. 2012 September; 342(3): 642-653.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34.
6	Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68(5):1254-70.
7	Benzamide derivatives as blockers of Kv1.3 ion channel. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1161-4.
8	Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. Biochemistry. 1999 Apr 20;38(16):4922-30.
9	Potent Kv1.3 inhibitors from correolide-modification of the C18 position. Bioorg Med Chem Lett. 2005 Jan 17;15(2):447-51.
10	Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun;65(6):1364-74.
11	Novel inhibitors of potassium ion channels on human T lymphocytes. J Med Chem. 1995 May 26;38(11):1877-83.