Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKQZB7)

Drug Name

1-(piperidin-4-ylmethyl)pyridin-2(1H)-one Drug Info

Synonyms

1-(piperidin-4-ylmethyl)pyridin-2(1H)-one; 2(1H)-Pyridinone, 1-(4-piperidinylmethyl)-; CHEMBL206887; SCHEMBL3217361; MolPort-008-735-437; ZINC13686304; AKOS010953288; 888729-52-0; 1-(piperidin-4-ylmethyl)-1,2-dihydropyridin-2-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44410571
TTD Drug ID: DMKQZB7

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Neuronal acetylcholine receptor alpha-2 (CHRNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rocuronium	DMY9BMK	Muscle spasm	MB47.3	Approved	[2]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[2]
Cisatracurium	DMUZPJ5	Muscle spasm	MB47.3	Approved	[2]
Vecuronium	DMP0UK2	Spasm	MB47.3	Approved	[2]
Levallorphan	DMCOLUP	Narcotic depression	6A7Z	Approved	[3]
Mivacurium	DM473VD	Anaesthesia	9A78.6	Approved	[2]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[3]
Pipecuronium	DM5F84A	Spasm	MB47.3	Approved	[3]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[1]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2)	TTF4E0J	ACHA2_HUMAN	Inhibitor	[1]

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References

1	Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6.
2	Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
3	Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.
4	Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1845-8.