Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKSIVL)

Drug Name

Selenazofurin Drug Info

Synonyms

Selenazofurin; 83705-13-9; UNII-I5R2V02E8Z; CI-935; 4-Selenazolecarboxamide, 2-beta-D-ribofuranosyl-; NSC 340847; BRN 4198668; I5R2V02E8Z; 2-beta-D-Ribofuranosyl-4-selenazolecarboxamide; 2-beta-D-Ribofuranosylselenazole-4-Carboxamide; C9H12N2O5Se; NSC340847; NSC-340847; RSC II; AC1L2P7R; SCHEMBL3051767; CHEMBL3144001; DTXSID80232569; CKMBACZHCFMPLQ-DBRKOABJSA-N; 2-ribofuranosylselenazole-4-carboxamide; PD-111232; LS-144766; 2 beta-ribofuranosylselenazole-4-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 100665
CAS Number: CAS 83705-13-9
TTD Drug ID: DMKSIVL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[3]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[4]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[1]
Mizoribine	DMW6F0S	Transplant rejection	NE84	Approved	[4]
Viramidine	DMJFNR9	Hepatitis C virus infection	1E51.1	Phase 3	[5]
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[6]
VX-148	DML32R8	Psoriasis vulgaris	EA90	Patented	[7]
PMID28074661-Compound-US20100022547C81	DMM9E1U	N. A.	N. A.	Patented	[6]
PMID28074661-Compound-US20120264760C80	DM75QVW	N. A.	N. A.	Patented	[6]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)	TTL7C8Q	IMDH1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	In vitro and in vivo antiproliferative activity of IPCAR, a new pyrazole nucleoside analog. Anticancer Res. 1998 Jul-Aug;18(4A):2623-30.
2	Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
3	Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13.
4	VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37.
5	Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
6	Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
7	Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.