Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKT0YQ)

Drug Name

8-Cyclohexyloxy-quinolin-2-ylamine Drug Info

Synonyms

CHEMBL185235; 8-Cyclohexyloxy-quinolin-2-ylamine; SCHEMBL5883787

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Melanin-concentrating hormone receptor 1 (MCHR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-830216	DMCW71N	Obesity	5B81	Phase 1	[2]
AZD1979	DMQ1OX4	Obesity	5B81	Phase 1	[3]
PMID25522065-Compound-27	DMXN4KB	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-29	DMBNAK9	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-34	DMZDIRQ	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-39	DM5YMQH	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-40	DMCIQ01	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-11	DM410Z6	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-50	DMBWA0V	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-12	DMVKO9C	N. A.	N. A.	Patented	[4]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7.
2	2011 Pipeline of Bristol-Myers Squibb.
3	Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc
4	Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207.