Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKTNBC)

Drug Name
Pyrazino[2,1-a]isoquinolin derivative 4 Drug Info
Synonyms PMID28454500-Compound-31
Cross-matching ID
TTD Drug ID
DMKTNBC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cysteines of Keap1 (KEAP1 Cysteines)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CXA10 DMM7Z6K Focal segmental glomerulosclerosis MF8Y Phase 2 [2]
PMID28454500-Compound-8 DM6BQFA N. A. N. A. Patented [1]
PMID28454500-Compound-36 DM5RZWG N. A. N. A. Patented [1]
Chalcone derivative 4 DM45COR N. A. N. A. Patented [1]
2-hydroxybenzamide derivative 1 DMER2ZQ N. A. N. A. Patented [1]
Vinyl sulfone derivative 1 DMTMFNK N. A. N. A. Patented [1]
Pyrazino[2,1-a]isoquinolin derivative 2 DMYXKQ3 N. A. N. A. Patented [1]
Diterpenoid derivative 1 DMAZOH4 N. A. N. A. Patented [1]
PMID28454500-Compound-13 DM7SIVA N. A. N. A. Patented [1]
PMID28454500-Compound-12 DMUY4LS N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Nuclear factor erythroid 2-related factor 2 (Nrf2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Omaveloxolone DMLMNFX Friedreich's ataxia 8A03.10 Approved [3]
CXA10 DMM7Z6K Focal segmental glomerulosclerosis MF8Y Phase 2 [2]
SFX-01 DMAQW9M Breast cancer 2C60-2C65 Phase 2 [4]
ABT-RTA-408 DM9Y1XB Non-small-cell lung cancer 2C25.Y Phase 2 [5]
OT-551 DMTNOXQ Ocular inflammation 9C61.24 Phase 2 [6]
OT551 DMHKIOF Age-related macular degeneration 9B75.0 Phase 2 [7]
HPP971 DMZXG7Q Non-alcoholic steatohepatitis DB92.1 Phase 1 [8]
PMID28454500-Compound-57 DMTK9M6 N. A. N. A. Patented [1]
PMID28454500-Compound-8 DM6BQFA N. A. N. A. Patented [1]
PMID28454500-Compound-36 DM5RZWG N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cysteines of Keap1 (KEAP1 Cysteines) TT3Z6Y9 KEAP1_HUMAN Modulator [1]
Nuclear factor erythroid 2-related factor 2 (Nrf2) TTA6ZN2 NF2L2_HUMAN Activator [1]

References

1 Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785.
2 The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev. 2017 Feb;9(1):41-56.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019 Apr;18(4):295-317.
5 National Cancer Institute Drug Dictionary (drug id 756624).
6 New hope for dry AMD. Nat Rev Drug Discov. 2013 Jul;12(7):501-2.
7 Nitroxide pharmaceutical development for age-related degeneration and disease. Front Genet. 2015 Nov 6;6:325.
8 Clinical pipeline report, company report or official report of vTv Therapeutics.