Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML0PFU)

• Drug Name: PMID24997608CA Drug Info
• Synonyms: 1599477-75-4; GPR120-IN-1; GPR120 Compound A; GTPL8418; MolPort-039-136-860; EX-A1318; BCP19379; BDBM50208095; ZINC209053267; AKOS025289518; CS-6429; HY-101492

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 73777063
  TTD Drug ID: DML0PFU

Molecule-Related Drug Atlas

Drug(s) Targeting G-protein coupled receptor 120 (GPR120)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[2]
GW9508	DMVKZ5I	Discovery agent	N.A.	Investigative	[3]
grifolic acid	DMGTRZE	Discovery agent	N.A.	Investigative	[4]
TUG-891	DMJRGZT	Discovery agent	N.A.	Investigative	[5]
NCG21	DMMRWJG	Discovery agent	N.A.	Investigative	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor 120 (GPR120)	TT08JVB	FFAR4_HUMAN	Agonist	[1]

References

• [1] A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7.
• [2] Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):515-22.
• [3] Free fatty acid receptors and drug discovery. Biol Pharm Bull. 2008 Oct;31(10):1847-51.
• [4] Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009 Sep;380(3):247-55.
• [5] Discovery of a potent and selective GPR120 agonist. J Med Chem. 2012 May 10;55(9):4511-5.
• [6] Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. J Med Chem. 2008 Dec 11;51(23):7640-4.