Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML4GU1)

Drug Name

99mTc-MIP-1404 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 2	[1]

Cross-matching ID

PubChem CID: 71300957
CAS Number: CAS 1333117-95-5
TTD Drug ID: DML4GU1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Glutamate carboxypeptidase II (GCPII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capromab	DMHERIJ	Prostate cancer	2C82.0	Approved	[3]
PSMA-11 Ga-68	DMWLTU2	Diagnostic imaging	N.A.	Approved	[4]
Lutetium Lu-177 vipivotide tetraxetan	DMQ0IZ6	Prostate cancer	2C82.0	Approved	[5]
177-Lu-PSMA-617	DMX178V	Prostate cancer	2C82.0	Phase 3	[6]
BAY 2315497	DMUHH2G	Prostate cancer	2C82.0	Phase 3	[7]
J 591 Lu-177	DM9XKJU	Prostate cancer	2C82.0	Phase 2	[8]
G-202	DMQR9I8	Adenocarcinoma	2D40	Phase 2	[9]
ATL101	DMYAQV2	Influenza virus infection	1E30-1E32	Phase 2	[10]
MLN-591RL	DMJHVZC	Prostate cancer	2C82.0	Phase 2	[11]
REGN5678	DM0Y6WU	Prostate cancer	2C82.0	Phase 1/2	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate carboxypeptidase II (GCPII)	TT9G4N0	FOLH1_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01667536) A Phase 2 Diagnostic Imaging Study With 99mTc-MIP-1404 in Men With High-Risk Prostate Cancer Scheduled for Radical Prostatectomy (RP) and Extended Pelvic Lymph Node Dissection (EPLND) Compared to Histopathology. U.S. National Institutes of Health.
2	99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer. J Nucl Med. 2013 Aug;54(8):1369-76.
3	Synergistic value of single-photon emission computed tomography/computed tomography fusion to radioimmunoscintigraphic imaging of prostate cancer. Semin Nucl Med. 2007 Jan;37(1):17-28.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
5	[177Lu-PSMA-617 therapy, dosimetry and follow-up in patients with metastatic castration-resistant prostate cancer]. Nuklearmedizin. 2016 Jun 28;55(3):123-8.
6	Review of 177Lu-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer. Cureus. 2020 Jun 30;12(6):e8921.
7	ClinicalTrials.gov (NCT03724747) Study to Evaluate the Safety, Tolerability,Pharmacokinetics, and Antitumor Activity of a Thorium-227 Labeled Antibody-chelator Conjugate Alone and in Combination With Darolutamide, in Patients With Metastatic Castration Resistant Prostate Cancer. U.S. National Institutes of Health.
8	Phase II study of Lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for metastatic castration-resistant prostate cancer. Clin Cancer Res. 2013 Sep 15;19(18):5182-91.
9	National Cancer Institute Drug Dictionary (drug id 666090).
10	Clinical pipeline report, company report or official report of Atlab pharma.
11	Indium 111-labeled J591 anti-PSMA antibody for vascular targeted imaging in progressive solid tumors. EJNMMI Res. 2015 Apr 29;5:28.
12	Clinical pipeline report, company report or official report of Regeneron Pharmaceuticals.