Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLQD6F)

Drug Name

RIG-200 Drug Info

Synonyms

1,3,4,6-Tetra-O-acetyl-2-[2(S)-(acetylamino)-3-methyl-3-(nitrososulfanyl)butyramido]-2-deoxy-beta-D-glucopyranose

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Discontinued in Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Guanylate cyclase soluble beta-1 (GUCY1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vericigiuat	DM104SP	Heart failure	BD10-BD13	Phase 2	[3]
Cinaciguat	DMGEAM6	Acute decompensated heart failure	BD1Z	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Guanylate cyclase soluble beta-1 (GUCY1B1)	TTLBYH1	GCYB1_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011948)
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES). Eur J Heart Fail. 2014 Sep;16(9):1026-38.
4	Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Circulation. 2009 Jun 2;119(21):2781-8.