Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLTVI6)

Drug Name

XAP044 Drug Info

Synonyms

7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Metabotropic glutamate receptor 7 (mGluR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[2]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[3]
L-CCG-I	DMPZ8XH	Discovery agent	N.A.	Investigative	[2]
(1S,3R)-ACPD	DM5DOAF	Discovery agent	N.A.	Investigative	[2]
(+)-MCPG	DMG5QJB	Discovery agent	N.A.	Investigative	[2]
MAP4	DMUCE93	Discovery agent	N.A.	Investigative	[2]
MPPG	DMJHQ9T	Discovery agent	N.A.	Investigative	[2]
[3H]LY341495	DMGX0Y8	Discovery agent	N.A.	Investigative	[2]
alpha-methylserine-O-phosphate	DMCIH1X	Discovery agent	N.A.	Investigative	[2]
L-AP4	DMPJFGI	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 7 (mGluR7)	TT0I76D	GRM7_HUMAN	Modulator (allosteric modulator)	[1]

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References

1	Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014 Apr 18;289(16):10975-87.
2	Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
3	Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9.