Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLXR90)

Drug Name
GNE-9605 Drug Info
Synonyms GNE 9605; GNE9605
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
76328936
TTD Drug ID
DMLXR90

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Leucine-rich repeat kinase 2 (LRRK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DNL151 DMZT89C Parkinson disease 8A00.0 Phase 1 [2]
DNL201 DMFEORD Parkinson disease 8A00.0 Phase 1 [2]
BIIB094 DMLUO5K Parkinson disease 8A00.0 Phase 1 [3]
Pyrrolo-pyridine derivative 2 DMVNY5I N. A. N. A. Patented [4]
Bidentate ligands of Markush derivative 2 DM2QNMC N. A. N. A. Patented [4]
Oxindole derivative 3 DM0ENF3 N. A. N. A. Patented [4]
Aminopyridine derivative 3 DMSLJE8 N. A. N. A. Patented [4]
Fused thiophene derivative 1 DMV7IX4 N. A. N. A. Patented [4]
Oxindole derivative 4 DM3U58I N. A. N. A. Patented [4]
Bidentate ligands of Markush derivative 1 DMB08D3 N. A. N. A. Patented [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leucine-rich repeat kinase 2 (LRRK2) TTK0FEA LRRK2_HUMAN Inhibitor [1]

References

1 Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of Ionis
4 Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676.