Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM1O0P)

Drug Name

BNC-102 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Leucine-rich repeat-containing GPCR 5 (LGR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MCLA-158	DMF0O3X	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
BNC-101	DMSBM6A	Metastatic colorectal cancer	2B91	Phase 1	[4]
KM-4056	DMK17GN	Solid tumour/cancer	2A00-2F9Z	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor 48 (LGR4)	TTY6C71	LGR4_HUMAN	Inhibitor	[2]
Leucine-rich repeat-containing GPCR 5 (LGR5)	TTTSGRH	LGR5_HUMAN	Inhibitor	[2]

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References

1	Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov. 2017 Sep;16(9):787-810.
2	Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov. 2017 Sep 1;16(9):661.
3	Clinical pipeline report, company report or official report of Merus.
4	Clinical pipeline report, company report or official report of Bionomics.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 148).