Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMBYGE)

Drug Name

Benzenesulfonyl Drug Info

Synonyms

benzenesulfinate; 16722-50-2; BENZENESULFONYL; phenylsulfinate; phenyl sulfinate; Phenylsulfinsaure; (Phenylsulfonyl)radical; AC1MYJCD; Benzenethiol S,S-dioxide; C6H5O2S; SCHEMBL13707414; CHEBI:38100; MolPort-019-857-533; JEHKKBHWRAXMCH-UHFFFAOYSA-M; STL483233; HTS027703; ZINC150345494; AKOS015890258; AB00990983-01

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3857574
ChEBI ID: CHEBI:38100
TTD Drug ID: DMMBYGE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VTB-38543	DMNY3J0	Atopic dermatitis	EA80	Phase 2	[2]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[1]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[3]
L-783483	DM6OTGE	Discovery agent	N.A.	Investigative	[4]
WAY-214950	DM8ODI7	Discovery agent	N.A.	Investigative	[5]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[6]
22R-hydroxycholesterol	DME8273	Discovery agent	N.A.	Investigative	[7]
GSK-9772	DM4WS3R	Discovery agent	N.A.	Investigative	[8]
Riccardin C	DM6MYGX	Discovery agent	N.A.	Investigative	[9]
2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione	DMH76SO	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxysterols receptor LXR-beta (NR1H2)	TTXA6PH	NR1H2_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26.
4	A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58.
5	Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8.
6	27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001 Oct 19;276(42):38378-87.
7	An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728-31.
8	Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem. 2008 Sep 25;51(18):5758-65.
9	Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85.
10	Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61.