Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMD9QE)

• Drug Name: Colistin Drug Info
• Synonyms: Colistin sulphate; Polymyxin E; Colistin sulfate, nonsterile; Polymyxin E. Sulfate; Coly-Mycin M Parenteral (TN)

Indication

Disease Entry	ICD 11	Status	REF
Pseudomonas infection	1B92	Approved	[1]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 5311054
  CAS Number: CAS 1066-17-7
  TTD Drug ID: DMMD9QE
  INTEDE Drug ID: DR2644

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[4]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[5]
Doripenem	DM9UCJK	Cholecystitis		Approved	[6]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[7]
Sulfisoxazole	DMXLT8C	Acute otitis media	AB00	Approved	[8]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[9]
Gramicidin D	DMPT74U	Bacterial infection	1A00-1C4Z	Approved	[10]
Oritavancin	DM28D05	Bacterial infection	1A00-1C4Z	Approved	[6]
Faropenem	DMX7A5V	Gram-positive bacterial infection	1B74-1G40	Approved	[6]
Daptomycin	DMFDQ3I	Bacterial infection	1A00-1C4Z	Approved	[11]

Drug(s) Metabolized By Endoglucanase Y (EGY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[3]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[3]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[3]
Bacitracin	DM5OHYE	Blepharoconjunctivitis		Approved	[3]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[3]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[3]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[3]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Dihydropteroate synthetase (Bact folP)	TT4ILYC	DHPS_ECOLI	Binder	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Endoglucanase Y (EGY)	DE2M583	A0A256VAC0_LACRE	Substrate	[3]
Endoglucanase Y (EGY)	DE2AZTG	A0A256VAC0_LACRE	Substrate	[3]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7.
• [3] Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.
• [4] In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.
• [5] Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94.
• [6] Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
• [7] The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
• [8] Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
• [9] A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6.
• [10] Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.
• [11] Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57.