General Information of Drug (ID: DMMEFO0)

Drug Name
COH29 Drug Info
Synonyms
Coh-29; COH-29; UNII-07802BU06S; 07802BU06S; 1190932-38-7; Rnr inhibitor COH29; SCHEMBL10036527; MolPort-044-567-552; AKOS032944935; CS-6153; HY-19931; N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide; Benzamide, N-(4-(3,4-dihydroxyphenyl)-5-phenyl-2-thiazolyl)-3,4-dihydroxy-
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
PubChem CID
44253415
CAS Number
CAS 1190932-38-7
TTD Drug ID
DMMEFO0

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [2]
CPX-POM DMK7DFM Bladder cancer 2C94 Phase 2 [3]
G-207 virus construct DM32AKH Glioma 2A00.0 Phase 1/2 [4]
Didox DM64CAS Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [5]
Trimidox DMY8GDA Solid tumour/cancer 2A00-2F9Z Preclinical [6]
Amidox DM3D0WA N. A. N. A. Terminated [7]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ribonucleotide reductase (RIR) TTX09M4 RIR1_HUMAN; RIR2_HUMAN; RIR2B_HUMAN Inhibitor [1]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30.
3 Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159.
4 Anti-tumor effect of oncolytic herpes simplex virus G47delta on human nasopharyngeal carcinoma. Chin J Cancer. 2011 Dec;30(12):831-41.
5 Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. Cancer Biol Ther. 2002 Sep-Oct;1(5):539-45.
6 Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea. Antiviral Res. 2002 Nov;56(2):167-81.
7 Metabolism of the new ribonucleotide reductase inhibitor amidox in the isolated perfused rat liver. Anticancer Res. 2000 Sep- Oct;20(5B):3521-6.