Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMG61B)

Drug Name

ACT-GRO-777 Drug Info

Synonyms

AGRO-100; AS-1411; Anticancer aptamers, Aptamera; GRO-26B; AGRO-100 derivatives, Aptamera; Nucleolin inhibitors (cancer), Aptamera; Nucleolin inhibitors (iv, acute myeloid leukemia), Advanced Cancer Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMMG61B

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Nucleolin (NCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Itarnafloxin	DMCY9PO	leukaemia	2A60-2B33	Phase 2	[3]
IPP-204106	DM8E3N6	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nucleolin (NCL)	TTCSZH7	NUCL_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT00740441) A Phase II Study of AS1411 in Renal Cell Carcinoma. U.S. National Institutes of Health.
2	Nucleic Acid Aptamers as Potential Therapeutic and Diagnostic Agents for Lymphoma. J Cancer Ther. 2013 June 1; 4(4): 872-890.
3	Targeting G-quadruplexes in gene promoters: a novel anticancer strategy . Nat Rev Drug Discov. 2011 April; 10(4): 261-275.
4	Company report (ImmuPharma)