Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMGWXQ)

Drug Name

FR-900452 Drug Info

Synonyms

101706-33-6

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3035856
CAS Number: CAS 101706-33-6
TTD Drug ID: DMMGWXQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Platelet-activating factor receptor (PTAFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[2]
RUPATADINE	DMBPN7T	N. A.	N. A.	Phase 4	[3]
ISRAPAFANT	DMP61YB	Asthma	CA23	Phase 3	[4]
CMI-392	DM1NCUY	Psoriasis vulgaris	EA90	Phase 2	[5]
Lexipafant	DMZ2YBE	Nerve injury	ND56.4	Phase 2	[6]
YM-264	DMAZNVX	Sepsis	1G40-1G41	Phase 2	[7]
Dersalazine	DMH96JW	Inflammatory bowel disease	DD72	Phase 2	[8]
60P002	DMHBN8X	Dengue	1D20-1D2Z	Phase 2	[9]
PegCNTF	DMW7VGZ	Obesity	5B81	Phase 1	[10]
FOROPAFANT	DML1DGP	Asthma	CA23	Discontinued in Phase 3	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet-activating factor receptor (PTAFR)	TTQL5VC	PTAFR_HUMAN	Modulator	[1]

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References

1	FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, a... J Antibiot (Tokyo). 1986 Feb;39(2):198-204.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43.
4	Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. J Biol Chem. 2010 Feb 19;285(8):5931-40.
5	Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. Pharmacol Res. 2001 Sep;44(3):213-20.
6	Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials.Eur J Surg.2002;168(4):215-9.
7	Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat. Biochem Biophys Res Commun. 1991 Apr 30;176(2):781-5.
8	The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012 February; 165(3): 729-740.
9	Clinical pipeline report, company report or official report of 60 Degrees Pharmaceuticals.
10	Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine. Agents Actions Suppl. 1991;34:313-21.
11	Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51.